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A photo of Prof CHIM Chor Sang, James
Prof CHIM Chor Sang, James
S H Ho Professorship in Haematology and Oncology
MBChB, MD, PhD, MRCP(UK), FRCP(London), FRCP(Edinburgh), FRCP(Glasgow), FACP, FRCPath(UK), FFSc(RCPA), FAcadTM, FHKAM, FHKCP
an email logo jcschim@hku.hk
a telephone logo 2255-4769
a fax logo 2816-2187

Biography

Prof Chim is the SH Ho Professor in Haematology & Oncology at the University of Hong Kong, and also an Honorary Consultant to the Department of Medicine at Queen Mary Hospital and an Honorary Oncology Specialist at the Department of Medicine and Geriatrics at Kwong Wah Hospital.
 
Professor Chim has been awarded Fellowships of both the Royal Colleges of Physicians and also Pathologists in the United Kingdom. He has also been awarded Founding Fellowship at the Faculty of Science of the Royal College of Pathologists of Australia & the Academy of Translational Medicine of the European Society for Translational Medicine (EUSTM). 
 
Prof Chim is a clinician scientist interested in the study of DNA methylation of tumour suppressor genes and non-coding RNAs (micro-RNAs & long noncoding RNAs) in blood cancers including multiple myeloma, lymphoma and chronic lymphocytic leukemia. So far, he has published >60 articles in the field of DNA methylation in blood cancers. Indeed, his research on “Epigenetic alterations in acute leukaemia” was awarded the prestigious State Scientific and Technological Advancement Award in China in 2009. Moreover, based on his original work in DNA methylation in blood cancer, he was awarded honorary fellowship of the Royal College of Pathologist of UK. He is also an invited member of Clinical Epigenetics Society (CLEPSO) and Cancer Epigenetics Society (CES). In this connection, he is also the associate editor of Epigenomics & Clinical Epigenetics. 
 
Moreover, Prof Chim is an international myeloma expert. He is a member of the International Myeloma Working Group (IMWG), Executive Council Member of Asian Myeloma Network (AMN), and the Chairman of the Education Program of the Asia Pacific Hematology Consortium (APHCON). Locally, he has established the Hong Kong Society of Myeloma (HKSOM), and is the Founding & current Chairman of HKSOM. He has served to formulate treatment protocols and organized clinical trials for myeloma patients in Hong Kong. Indeed, he has published & presented the clinical outcomes of myeloma patients in Hong Kong in international journals & meetings. Last but not least, Prof Chim has been helping the myeloma patients and relatives in HK to organize patient gatherings and sharing sessions. Indeed, the first patient gathering in Oct, 2015 has been published in “Myeloma Today”, a periodical of the International Myeloma Foundation, in March 2016, and the number of attendants expanded from ~60 in the first to ~120 in the last gathering in Oct 2016. 
 
Furthermore, Prof Chim has been invited abstract reviewer for American Society of Hematology (ASH) and external reviewer for prestigious grant funding organizations including Leukaemia & Lymphoma Research, Leukemia Research (United Kingdom), Cancer Research (United Kingdom), The Agency for Science, Technology and Research (A*Star) of Singapore, & Association for International Cancer Research (AICR), U.S.-Israel Binational Science Foundation (BSF), the Icelandic Research Fund (IRF), Swiss National Science Foundation (SNSF) & Czech Science Foundation.
 
Besides, Professor Chim has published extensively. He has authored >230 publications, being major & corresponding in the majority, in international peer reviewed journals. He is also the Editor-in-Chief of the Journal of Genetics Study & RNA & Disease, Associate Editor of Epigenomics, Clinical Epigenetics, Frontiers in Oncology, & Hematology, & Senior/Scientific Editor of the American Journal of Translational Research & Translational Oncology. Further, Professor Chim also sits on the Editorial Board of many journals including Blood Cancer Journal, Bone Marrow Transplantation, Journal of Hematology & Oncology & Journal of Translational Medicine.
 
In addition to his wide international recognition, Professor Chim is also widely known in mainland China, and is currently the honorary/visiting Professors of many universities in China including Peking University People’s Hospital, Chinese PLA Postgraduate Medical School & PLA General Hospital of Beijing, Sichuan University, Soochow University, Tongji Medical University of Wuhan.

Selected Publications

  1. Chng WJ, Dispenzieri A, Chim CS, Fonseca R, Goldschmidt H, Lentzsch S, Munshi N, Palumbo A, Miguel JS, Sonneveld P, Cavo M, Usmani S, Durie BG, Avet-Loiseau H. IMWG consensus on risk stratification in multiple myeloma. Leukemia. 2014 Feb;28(2):269-77.
  2. Wang LQ, Kwong YL, Kho CS, Wong KF, Wong KY, Ferracin M, Calin GA, Chim CS. Epigenetic inactivation of miR-9 family microRNAs in chronic lymphocytic leukemia--implications on constitutive activation of NFκB pathway. Mol Cancer. 2013 Dec 27;12:173.
  3. Zhang MY, Fung TK, Chen FY, Chim CS. Methylation profiling of SOCS1, SOCS2, SOCS3, CISH and SHP1 in Philadelphia-negative myeloproliferative neoplasm. J Cell Mol Med. 2013 Oct;17(10):1282-90.
  4. Wong KY, Yim RL, Kwong YL, Leung CY, Hui PK, Cheung F, Liang R, Jin DY, Chim CS. Epigenetic inactivation of the MIR129-2 in hematological malignancies. J Hematol Oncol. 2013 Feb 14;6:16.
  5. Yim RL, Kwong YL, Wong KY, Chim CS. DNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin's Lymphomas. Front Genet. 2012 Nov 8;3:233.
  6. Wang LQ, Liang R, Chim CS. Methylation of tumor suppressor microRNAs: lessons from lymphoid malignancies. Expert Rev Mol Diagn. 2012 Sep;12(7):755-65.
  7. Wong KY, Huang X, Chim CS. DNA methylation of microRNA genes in multiple myeloma.Carcinogenesis. 2012 Sep;33(9):1629-38.
  8. Chim CS, Lie AK, Chan EY, Liu HS, Lau CW, Yip SF, Sim J, Wan TS, Ma ES, Liang R, Tse E, Kwong YL; Hong Kong Society of Myeloma. Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD. J Hematol Oncol. 2012 Jun 8;5:28.
  9. Wong KY, Yu L, Chim CS. DNA methylation of tumor suppressor miRNA genes: a lesson from the miR-34 family. Epigenomics. 2011 Feb;3(1):83-92.
  10. KY Wong, Rita LH Yim, CC So, DY Jin, Raymond Liang, Chim CS. Epigenetic inactivation of the MIR34B/C in multiple myeloma. Blood 2011; 118: 5901-5904 (Impact Factor: 9.060).
  11. Kwan-Yeung Wong, Raymond Liang, Chi-Chiu So, Yanting Qi, Dong-Yan Jin, Joseph F. Costello, Chim CS. Epigenetic silencing of miR-203 in multiple myeloma. Br J Haematol, 2011 Sep; 154(5): 569-78. (Impact Factor: 4.942).
  12. Chim CS, KY Wong, Y Qi, Loong F, WL Lam, LG Wong, Jin DY, Costello JF, Liang R. Epigenetic inactivation of the miR-34a in hematological malignancies. Carcinogenesis, 2010, 31(4):745-50 (Impact Factor: 5.635).
  13. Chim CS, Pang R, Fung TK, Choi CL, Liang R. Epigenetic Dysregulation of Wnt Signaling Pathway in Multiple Myeloma. Leukemia; 21(12): 2527-36, 2007 (Impact Factor: 10.164).
  14. Chim CS, Wong SY, Pang A, Chu P, Lau JS, Wong KF, Kwong YL. Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia. Leukemia. 2005 Dec;19(12):2241-6 (Impact Factor: 10.164).
  15. Chim CS, Kwong YL, Lie AK, Ma SK, Chan CC, Wong LG, Kho BC, Lee HK, Sim JP, Chan CH, Chan JC, Yeung YM, Law M, Liang R. Long-term outcome of 231 patients with Essential Thrombocythemia: Prognostic factors for bleeding, thrombosis, myelofibrosis and leukaemia. Archives Int Med, 2005, 165: 2651-2658 (Impact Factor: 10.579).
  16. Chim CS, Ma SY, Au WY, Choy C, Lie AK, Liang R, Yau CC, Kwong YL. Primary nasal natural killer cell lymphoma: long-term treatment outcome and relationship with the International Prognostic Index. Blood 2004, 103: 216-221 (Impact Factor: 9.060).
  17. Chim CS, Fung TK, Cheung WC, Liang R, Kwong YL. SOCS1 and SHP1 Hypermethylation in Multiple Myeloma: Implications for Epigenetic Activation of the Jak/STAT pathway. Blood 2004; 103: 4630-4635(Impact Factor: 9.060).
  18. Chim CS, Liang R, Tam CY, Kwong YL. Methylation of p15 and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance. J Clin Oncol, 19: 2033-2040, 2001 (Impact Factor: 18.038).

Grant Record

 
Research Title Role Grant Source Date of Grant
Identification of methylated microRNAs in acute promyelocytic leukaemia & their potential clinical application PI HMRF (HKD996,808) 2016-2018
Mechanism study of the effect of microenvironment on RANKL expression in myeloma cells PI NSFC (CNY75.0000) 2016-2018
Study of methylation of microRNA in mantle cell lymphoma PI RGC (HKD800,000) 2012-2014
Functional study of the impact of hypermethylation of tumor suppressive mico-RNA in myeloma stem cells PI RGC (HKD944,700) 2010-2012

Key Offices

  1. Honorary Consultant: Queen Mary Hospital
  2. Member, Licentiate Committee Internship, The Medical Council of Hong Kong (since 2015)
  3. Scientific Member, Institutional Review Board, The University of Hong Kong / Hospital Authority Hong Kong West Cluster (since 2013)
  4. Member: International Myeloma Working Group, IMWG
  5. Founding & Current Chairman: the Hong Kong Society of Myeloma
  6. Chairman, the Hong Kong Society of Myeloma, 2010-now
  7. Chairman, Education Program, Asia Pacific Hematology Consortium (APHCON) (since 2012)
  8. Haematology & Haematological Oncology : Board Member (1999-2015) & Examiner ( 2006-now)
  9. Program Director: Specialty Board in Haematology and Haematological Oncology, Hong Kong College of Physicians (2010-2015)
  10. Member, Pharmacy and Poisons Board Hong Kong - Pharmacy and Poisons Committee, Department of Health (Jan 2016- Dec 2017)
  11. Member, Health and Medical Research Fund (HMRF) Grant Review Board, organized by Food and Health Bureau, The Government of HKSAR (Nov, 2013 – Oct, 2017)
  12. Consultant of the American College of Physicians: Physicians' Information and Education Resources (PIER)(Jan 2008-Dec 2011)
  13. Chairman of the HK Society of Haematology (2004-2006)

Esteem Measures

  • State Scientific and Technological Advancement Award, China             2009
    • (國家科學技術進步獎 (二等獎 ))    
  • the Croucher Foundation Fellowship in 1992.

Editorial Board Memberships

  1. Editor-in-Chief:
    • Journal of Genetics Study
    • RNA & Disease
  2. Associate Editor
    • Clinical Epigenetics (IF: 4.327)
    • Epigenomics (impact factor: 4.044)
    • Frontiers in Oncology
    • Hematology (IF: 1.385)
  3. Editorial Board Members
    • Carcinogenesis (impact factor : 4.874) (Jan 2009-Dec 2011)
    • Journal of Hematology Oncology (impact factor: 6.232)
    • Blood Cancer Journal (impact factor: 4.411)
    • Journal of Translational Medicine (impact factor: 3.694)
    • Bone Marrow Transplantation (impact factor :3.636)
    • American Journal of Translational Research (IF: 3.146)
    • Translational Oncology (impact factor: 3.077)
    • PLoS ONE (impact factor : 3.057)
    • International Journal of Oncology (impact factor: 3.018)
    • Current Oncology Reports (impact factor: 2.653)

Leadership position of international organizations

  • Member: International Myeloma Working Group (IMWG)
  • Executive Council Member: Asia Myeloma Network (AMN)
  • Chairman: Education Program, Asia Pacific Hematology Consortium (APHCON)
  • Invited member, Clinical Epigenetics Society (CLEPSO) 
  • Invited member, Cancer Epigenetics Society (CES)
  • Invited member, Chinese American Hematologists and Oncologists (CAHON)

Visiting / Honorary Professors

  1. Peking University People's Hospital (北京大學人民醫院) (2012-now)
  2. Chinese PLA Postgraduate Medical School & PLA General Hospital (北京中國人民解放軍總醫院) (PLA) (2010-now)
  3. Soochow University, Suzhou, China (蘇州大學)(2013-now)
  4. Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (武漢華中科技大學) (2009-now)
  5. Visiting Professor: West China Hospital, Sichuan University  (四川大学华西医院) (Jul 2015- 2017)
  6. Capital Medical University, Beijing (首都醫科大學) (2011-now)
  7. Shandong University (山東大學) (2011-2014)
  8. Sun Yat-Sen University, Guangzhou, China (中山大學) (2010-2012)
  9. Sun Yat-Sen Institute of Hematology (中山大學血液學研究所) (2010-2012)
  10. Nanfong Medical University, Quangzhou  (南方醫科大學) (2008-2011)
  11. Chair Professor: Sun Yat-Sen Institute of Hematology (中山大学血液學研究所) (2010-2012)