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Research Interest

1. lupus nephritis – clinical studies

2. lupus immuno-pathogenesis

3. matrix deposition and fibrosis in kidney diseases
   
   
   

Selected Publications

1. Yung S, Chau MKM, Zhang Q, Zhang CZ, Chan TM. Sulodexide decreases albuminuria and regulates matrix protein accumulation in C57BL/6 mice with streptozotocin-induced type I diabetic nephropathy. PLoS ONE, 2013; 8: e54501 [impact factor: 4.092].

2. Lui SL, Yung S, Yim A, Wong KM, Tong KL, Wong KS, Li CS, Au TC, Lo WK, Ho YW, Ng F, Tang C, Chan TM. A combination of biocompatible peritoneal dialysis solutions and residual renal function, peritoneal transport, and inflammation markers: a randomized clinical trial. Am J Kidney Dis 2012; 60: 966-975 [impact factor: 5.434, citations: 1].

3. Yung S, Cheung KF, Zhang Q, Chan TM. Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis. J Am Soc Nephrol 2010; 21: 1912-1927 [impact factor: 9.663, citations: 8].

4. Yung S, Zhang Q, Zhang CZ, Chan KW, Lui SL, Chan TM. Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid. Arthritis Rheum 2009; 60: 2071-2082 [impact factor: 7.866, citations: 7].

5. Yung S, Tsang RC, Sun Y, Leung JK, Chan TM. Effect of human anti-DNA antibodies on proximal renal tubular epithelial cell cytokine expression: implications on tubulointerstitial inflammation in lupus nephritis. J Am Soc Nephrol 2005; 16: 3281-3294 [impact factor: 9.663, citations: 14].

6. Chan TM, Tse KC, Tang CS, Mok MY, Li FK. Long-term study of mycophenolate mofetil as continuous induction and maintenance treatment for diffuse proliferative lupus nephritis. J Am Soc Nephrol 2005; 16: 1076-1084 [impact factor: 9.663, citations: 240].

7. Yung S, Chen XR, Tsang RC, Zhang Q, Chan TM. Reduction of perlecan synthesis and induction of TGF-beta1 in human peritoneal mesothelial cells due to high dialysate glucose concentration: implication in peritoneal dialysis. J Am Soc Nephrol 2004; 15: 1178-1188 [impact factor: 9.663, citations: 16].

8. Chan TM, Li FK, Tang CS, Wong RW, Fang GX, Ji YL, Lau CS, Wong AK, Tong MK, Chan KW, Lai KN. Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong Kong-Guangzhou Nephrology Study Group. N Engl J Med 2000; 343: 1156-1162 [impact factor: 53.293, citations 565].
   
   

Key Offices

1. President, Asian Pacific Society of Nephrology 2008-2010

2. Past President, Hong Kong Society of Transplantation

3. Nephrology Board Chairman, Hong Kong College of Physicians

4. Associate Dean, LKS Faculty of Medicine, University of Hong Kong