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Prof KUNG Wai Chee, Annie MBBS(HK), MD, FHKCP, FHKAM(Med), FRCP(Lond), FRCP(Edin), FRCP (Glas)

Research Interest

1. Epidemiology and genetic studies of osteoporosis

2. Genetic study of Thyrotoxic Periodic Paralysis

3. Clinical Trials and Drug Discovery in osteoporosis

4. Complications of hyperthyroidism, thyrotoxic periodic paralysis, thyroid diseases in pregnancy
   
   
   

Selected Publications

1. Huang QY, Li GHY, Kung AWC (Corresponding Author). The cis-regulatory polymorphism rs1230399 of the sclerosteosis gene that affects C/EBP? and FOXA 1 binding is associated with osteoporosis. The Journal of Clinical Endocrinology and Metabolism (Accepted)

2. Cheung CL, Chan BYY, Chan V, Ikegawa S, Kou I, Ngai HHY, Smith D, Huang QY, Mori S, Sham PC, Kung AWC (Corresponding Author). Pre-B-Cell Leukemia Homeobox 1 (PBX1) Shows Genetic and Functional Association with Bone Mineral Density Variation. Human Molecular Genetics 2009;18(4):679-87

3. Tang PLF, Cheung CL, Sham PC, McClurg P, Lee B, Chan SY, Smith DK, Tanner JA, Su AI, Cheah KSE, Kung AWC (Co-corresponding Author), Song YQ. Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with bone mineral density and fracture in southern Chinese women. Journal of Bone & Mineral Research 2009;24:1013-1021

4. Kung AWC (Corresponding Author), Lee KK, Ho AYY, Tang G, Luk KDK. Ten-Year Risk of Osteoporotic Fractures in Postmenopausal Chinese Women According to Clinical Risk Factors and BMD T Scores: A Prospective Study. Journal of Bone and Mineral Research 2007;22:1080-7

5. Ioannidis JPA, Ng MY, Sham PC, Zintzaras E, Lewis C, Deng HW, Econs MJ, Karasik D, Devoto M, Kammerer CM, Spector T, Andrew T, Cupples LA, Duncan EL, Foroud T, Kiel DP, Koller D, Langdahl B, Mitchell BD, Peacock M, Recker R, Shen H, Sol-Church K, Spotila LD, Uitterlinden AG, Wilson SG, Kung AWC (Co-corresponding Author). Ralston SH. Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass. Journal of Bone and Mineral Research 2007;22:173-83

6. Kung AWC. Clinical Review: Thyrotoxic periodic paralysis: a diagnostic challenge (Invited Review). Journal of Clinical Endocrinology and Metabolism 2006:91:2490-5
   

Key Offices

1. Chairman, Asia Pacific Panel, International Society for Clinical Densitometry

2. National Societies Committee, International Osteoporosis Foundation

3. Founding President, The Osteoporosis Society of Hong Kong