TSE Hung Fat - Chair Professor of Cardiovascular Medicine, William MW Mong Professor in Cardiology MBBS.
MD, PhD, FRCP (Lond, Edin, Glasg), FACC, FHKCP, FHKAM
Tel: 2255 3598
Fax: 2818 6304
Basic and clinical
therapies, such as medical devices and gene-based approaches
for cardiac arrhythmias;
of cardiovascular system, such as vascular ultrasound, CT
scan and MRI; and
regenerative medicine using gene-based and cell-based, including
adult, embryonic and induced pluripotent stem cells.
Tse HF, Kwong YL,
Lo G, Ho CL, Chan JKF, Yeung DW, Lau CP. Angiogenesis
in ischemic myocardium by intramyocardial autologous bone
marrow mononuclear cell implantation. Lancet 2003;361:47-49.
Tse HF, Reek S,
Timmermans C, Lee KLF, Geller C, Rodriguez LM, Ghaye B, Ayers
GM, Crijns HJGM, Klein HU, Lau CP. Pulmonary vein isolation
using transvenous catheter cryoablation for atrial fibrillation
without the risk of pulmonary vein stenosis. Am J Coll
Liu B, Wang J,
Chan KM, Tjia WM, Deng W, Guan X, Huang J, Li KM, Chan JD,
Pei D, Pendas A, Lopez-Otin C, Tse HF, Hutchison C, Chen J,
Cao Y, Cheah KSE, Tryggvason K, Zhou Z. Genomic instability
in laminopathy-based premature aging. Nat Med 2005; 11:
Tse HF, Xue T,
Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li
RA. A bio-artificial sinus node constructed via in vivo
gene transfer of an engineered pacemaker (HCN) channel reduces
the dependence on electronic pacemaker in a sick sinus syndrome
model. Circulation. 2006;114:1000-11.
Tse HF, Thambar
S, Kwong YL, Rowlings P, Bellamy G, McCrohon J, Thomas P.
Bastian B, Chan JKF, Lo G, Ho CL, Chan WS, Kwong RY, Parker
A, Hauser T, Chan J, Fong YT, Lau CP. Prospective randomized
trial of direct endomyocardial implantation of bone marrow
cells for therapeutic angiogenesis in severe coronary artery
diseases. Eur Heart J. 2007 Dec;28(24):2998-3005.
Connolly SJ, Camm AJ, Halperin J, Joyner C, Hart R, Alings M, Amerena J, Atar D, Avezum A, Blomström P, Borgreffe M, Budaj A, Chen SA, Ching CK, Commerford P, Dans A, Marc Davy J, Delacrétaz E, Di Pasquale G, Diaz R, Dorian P, Flaker G, Golitsyn S, Gonzalez-Hermosillo A, Granger C, Heidbüchel H, Kautzner J, Kim JS, Lanas F, Lewis B, Merino JL, Murin J, Narasimhan C, Paolasso E, Parkhomenko A, Peters NS, Sim KH, Stiles M, Tanomsup S, Toivonen L, Tomcsányi J, Torp-Pedersen C, Tse HF, Vardas P, Vinereanu D, Xavier D, Zhu J, Zhu JR, Baret-Cormel L, Weinling E, Staiger C, Yusuf S, Chrolavicius S, Afzal R, Hohnloser SH, on behalf of the PALLAS Investigators. Effects of Dronedarone in Permanent Atrial Fibrillation. N Engl J Med. 2011;365:2268-76.
Lian Q*, Zhang Y, Zhang J, Zhang HK, Wu X, Zhang Y, Lam FY, Kang S, Xia JC, Lai WH, Au KW, Chow YY, Siu CW, Lee CN, Tse HF*. Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation 2010;121:1113-23. (*corresponding author)
Lip GY, Tse HF, Lane DA. Management of atrial fibrillation. Lancet 2012 18;379:648-61.
Zhang J, Lian Q, Zhu G, Zhou F, Sui L, Tan C, Abdul Mutalif R, Navasankari R, Zhang Y, Tse HF, Stewart CL, Colman A. A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell. 2010;8:31-45.
Lau CP, Tachapong N, Wang CC, Wang JF, Abe H, Kong CW, Liew R, Shin DG, Padeletti L, Kim YH, Omar R, Jirarojanakorn K, Kim YM, Chen MC, Sriratanasathavorn C, Munawar M, Kam R, Chen JY, Cho YK, Li YG, Wu SL, Bailleul C, Tse HF*, for SAFE Study Prospective Randomized Study to Assess the Efficacy of Site and Rate of Atrial Pacing on Long-term Progression of Atrial Fibrillation in Sick Sinus Syndrome- Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) study. Circulation 2012;128:687-93. (*corresponding author).
Tse HF*, Ho JC, Buter AW, Lee YK, Choi SW, Ng KM, Siu CW, Simpson MA, Lai WH, Chan YC, Zhang J, Lay KW, Esteban MA, Colman A, Sham PC. Patient-specific induced pluripotent stem cells derived cardiomyocytes recapitulates the pathogenic phenotypes of dilated cardiomyopathy due to a novel desmin gene mutation identified by whole exome sequencing. Hum Mol Genet 2013;22:1395-1403. (*corresponding author).
Lau CP, Siu CW, Tse HF. The future of implantable devices for cardiac rhythm management. Circulation 2013 (in press).
2005- present Honorary Consultant, Department of Medicine, Queen Mary Hospital, Hospital Authority
2006- present Clinical Professor, Department of Medicine, The University of Hong Kong
2006- present Honorary Consultant, Department of Medicine, Kwong Wah Hospital, Hospital Authority
2007- present Academic Chief, Cardiology Division, Department of Medicine, The University of Hong Kong
2007-present Honorary Consultant, Department of Medicine, Tung Wah Hospital, Hospital Authority
2007-present Honorary Consultant, Department of Medicine, Ruttonjee Hospital, Hospital Authority
2008-present William MW Mong Professorship in Cardiology, LKS Faculty of Medicine, the University of Hong Kong
2011-present Professor, Chair of Cardiovascular Medicine, LKS Faculty of Medicine, the University of Hong Kong
2012-present Honorary Consultant, Hong Kong Sanatorium and Hospital