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Dr TSE Wai Choi, Eric BSc (BiomedSc), MBBS (HK), PhD (Cantab), FRCP (Lond), FRCPath, FHKCP, FHKAM (Medicine) Email: ewctse@hku.hk Tel: 2255 4794 Fax: 2872 6896

Research Interest

1. Cell signaling in cancers

2. Role of prolyl-peptide-isomerase PIN1 in cancer pathogenesis and metastasis

3. Development of novel targeted therapy for cancer treatment

4. Treatment of chronic lymphocytic leukaemia and other lymphoproliferative disorders

5. Clinical study on venous thromboembolism
   
   
   

Selected Publications

1. Tse E and Rabbitts TH. Intracellular antibody-caspase medicated cell killing: an approach for application in cancer therapy. Pro. Natl. Acad. Sci. USA. 97(22): 12266-71, 2000

2. Tse E, Lobato MN, Forster A, Tanaka T, Chung GT and Rabbitts TH. Intracellular Antibody Capture Technology: Application to selection of intracellular antibodies recognizing the BCR-ABL oncogenic protein. J. Mol. Biol. 317(1): 85-94, 2002

3. Pang R, Yuen J, Yuen MF, Lai CL, Lee TK, Man K, Poon RT, Fan ST, Wong CM, Ng IO, Kwong YL and Tse E. PIN1 over-expression and ß-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma. Oncogene 23(23): 4182-6, 2004

4. Pang R, Lee TK, Man K, Poon RT, Fan ST, Kwong YL and Tse E. PIN1 expression contributes to hepatic carcinogenesis. J. Pathol. 210(1):19-25, 2006

5. Pang R, Lee TK, Poon RT, Fan ST, Wong KB, Kwong YL and Tse E. Pin1 interacts with a specific serine-proline motif of hepatitis B virus x-protein to enhance hepatocarcinogenesis. Gastroenterology. 32(3):1088-103, 2007

6. Leung J, Pang A, Yuen WH, Kwong YL and Tse E. Relationship of expression of aquaglyceroporin 9 with arsenic uptake and sensitivity in leukaemia cells. Blood. 109(2):740-46, 2007
   

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